ABackground: multifocal atherosclerotic disease (MAD) is a summary of asymptomatic or symptomatic atherosclerotic changes in different vascular beds, extremities with arterial occlusive disease (AOD), cerebrovascular disease (CVD), renal artery disease, coronary artery disease (CAD). The changes rise up simultaneosly and from multiple risk factors (MRF) and other co-morbidity factors depends where the clinical events is going to be targeted. Methods: we included 109 consecutive patients treated at our Institute in the period Dec 1999 - Dec 2000, all with clear arterial occlusive disease (AOD). We evaluated clnical variables: age, gender, arterial hypertension (HTA), tobacco, hyperlipidemia (HLP), obesity (BMI), fibrinogen and diabetes mellitus.Score of MRF was calculated as x/8. Co-morbidity as coronary heart disease (CHD), and cerebrovascular disease (CVD) was evaluated and correlate to MRF score. All pts. were evaluated according to clinical evidence of CHD and CVD, respectively. Results: we had 104 pts, 88 males and 16 females, average age of 62 yrs, males 63 and females 60 yrs. Out of total number of pts. (n-104), 44 pts. were hypertensive (42,3%), 95 with tobacco use (91%), 42 pts with HLP (40,4%), 26 pts. with DM (25%), 23 pts. with obesity (22,2%), 39 pts. with fibrinogen (37,5%). In whole group (n-104), multifocal atherosclerotic disease, AOD+CHD, had 21 pts. (MRF score 4,4), AOD+CVD had 8 pts. (MRF score 3,6), and AOD+CHD+CVD had 8 pts (7,7%) (MRF score 4,4). Among clinical variables, tobacco was of very high risk, with 95 pts. positive (91%), what is of high significance, p<0,0001. Conclusions: the most common co-morbidity in our group of pts.was AOD+CHD, with correlation rank to MRF score of r=.66 (p< 0,01). Co-morbidity with CVD was of borderline correlation, r=.38 (p=0,06). It might be due to high presence of asymptomatic carotid stenosis.I

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