IMUNI ODGOVOR NA EPIKUTANO ALERGIJSKO TESTIRANJE U PACIJENATA SA KONTAKTNIM ALERGIJSKIM DERMATITISOM: DOBNE I SPOLNE RAZLIKE
Sijerčić N 1, Pranjić N 2, Hadžigrahić N 1, Suljagić E 1.
1 Univerzitetski Klinički Centar, Klinika za dermatologiju, Tuzla, Bosna i Hercegovina
2 Univerzitetski Klinički Centar, Zavod za Medicinu rada, Tuzla, Bosna i Herzegovina

CILJ: Cilj ove studije je analizirati odnos tipa uzročnih alergena prema dobu i spolu u pacijenata sa kontaktnim alergijskim dermatitisom (KAD).

ISPITANICI I METODE: Studijom koja je bila provedena od 1988. do 1998. godine, obuhvaćeno je 495 pacijenata sa kliničkom slikom KAD-a (183 muškog-37% i 312-63% ženskog spola), starosne dobi od 18-60 godina. Svim pacijentima je urađeno epikutano testiranje sa standardnom serijom od 18 kontaktnih alergena (Evropska standardna serija).

REZULTATI: Pozitivnu alergijsku reakciju imalo je 58,65% pacijenata ženskog i 58,47% pacijenata muškog spola, bez statističke značajnosti (P>0.05). Uočena je razlika u frekventnosti uzročnih alergena, pa su u osoba ženskog spola najučestaliji: Nikal sulfat (27,56%), Parafenilendiamin (12,82%), Kalijum dihromat (11,22%) i Kobalt hlorid (9,94%), a u muškog spola su to: Kalij dihromat (24,04%), Kobalt hlorid (17,49%), zatim Parafenilendiamin (12,02%) i Nikal sulfat (9,84%). Srednja starosna dob žena sa pozitivnom alergijskom reakcijom bila je 33,79 ± 9,44 godina, a žena bez alergijske reakcije 36,16 ±9,75 godina (P<0,05). Srednja starosna dob muškaraca sa alergijskom reakcijom bila je 35,62 ±10,55 godina, a muškaraca bez alergijske reakcije bila je 38,29 ± 9,75 godina (P<0,05).

ZAKLJUČAK: Ispitanici oba spola dali su podjednak imuni odgovor na izloženost kontaktne alergene, ali su utvrđene razlike u vrsti alergena. Mlađe osobe, oba spola su podložnije kontaktnoj senzibilizaciji.

THE IMMUNE RESPONSE OF PATIENTS WITH CONTACT ALLERGIC DERMATITIS: AGING AND GENDER DIFFERENCES

Sijercic N 1, Pranjic N 2, Hadzigrahic N 1, Suljagic E 1.
1 University Clinical Centre, Department of Dermatology, Tuzla, Bosnia and Herzegovina
2 University Clinical Centre, Department of Occupational Medicine, Tuzla, Bosnia and Herzegovina

AIM: The purpose of this study is to analyze relationship between specific allergens towards gender and age structure of patients with contact allergic dermatitis (CAD).

SUBJECTS AND METHODS: Having applied retrospective analysis of 495 persons has been examined in total with clinical CAD (183 were men-37% and 321-63% women). With regards to their age it varied from 18-60 years of age. All patients were exposed to patch examination of standard series of 18 allergens as integral part of European Standardized Series.

RESULTS: Positive allergic reaction was noticed with 58,65% of female patients, and 58,47% of male patients, without significant statistical difference (P>0,05). We found difference in frequency of caused allergens and in female patients has been proved in following allergens: Nickel sulphate (27,56%), Parafenylendiamin (12,82%), Potassium dichromate (11,22%), and Cobalt-chloride (9,94%). And in male patients has been proved: Potassium dichromate (24,04%), Cobalt chloride (17,49%), Parafenylendiamin (12,02%), and Nickel sulphate (9,84%). Average age of women patients with positive reaction was 33,79 +/- 9,44; and average age of women who did not have reaction is 36,16 +/- 9,75 (P<0,05). Average age of male patients with the positive reaction was 35,62 +/- 10,55 and age of men without reaction was 38,29 +/- 9,75 (P< 0,05).

CONCLUSION: Both sexes gave the equal immune response to exposure to contact allergens, but differences were determined in the category of the type of standard allergens. In both sexes younger patients are more sensitive to contact allergens.